A new highly oxygenated pseudoguaianolide from a collection of the
flowers of Parthenium hysterophorus.

Das R, Geethangili M, Majhi A, Das B, Rao YK, Tzeng YM.

Department of Chemistry, Gurudas College, Kolkata, India.
Chem Pharm Bull (Tokyo). 2005 Jul;53(7):861-2.

A new highly oxygenated pseudoguaianolide, 8-beta-acetoxyhysterone C,
along with the known compounds, parthenin, coronopilin and hysterone
C, has been isolated from a collection of the flowers of Parthenium
hysterophorus. The structure of the new compound was derived from the
extensive studies of its spectral (mainly 1D and 2D NMR) data.
==========================================================
Comparison of patch test contact sensitivity to acetone and aqueous
extracts of Parthenium hysterophorus in patients with airborne
contact dermatitis.

Sharma VK, Sethuraman G, Tejasvi T.

Department of Dermatology & Venereology, All India Institute of
Medical Sciences, New Delhi 110029, India. aiimsvks@...

Our aim was to compare the degree of patch test positivity to acetone
and aqueous extracts of Parthenium hysterophorus in patients with
airborne contact dermatitis. We performed patch testing with the
Indian standard series (which includes aqueous extracts of
parthenium, xanthium and chrysanthemum), and with 1 : 100 and 1 : 200
dilutions of an acetone extract of parthenium in 72 patients with
airborne contact dermatitis. All patients showed contact sensitivity
to the 1 : 100 dilution and 67 patients had positive allergic
reactions to the 1 : 200 dilution of the acetone extract, whereas
only 45 patients showed a positive reaction to the aqueous extract of
P. hysterophorus. Our results confirm that parthenium allergens are
more soluble in acetone than in water, and that the acetone extract
is significantly better in detecting contact sensitivity to
parthenium in patients with suspected plant dermatitis. Hence, the
acetone extract is recommended for routine patch testing.

Contact Dermatitis. 2004 Apr;50(4):230-2.

============================