Phytochemistry. 2007 Aug;68(15):2029-34. Epub 2007 Jun 13. Related
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Acetylated pseudoguaianolides from Parthenium hysterophorus and
their cytotoxic activity.

Das B, Reddy VS, Krishnaiah M, Sharma AV, Ravi Kumar K, Rao JV,
Sridhar V.

Organic Chemistry Division-I, Indian Institute of Chemical
Technology, Hyderabad 500 007, India. biswanathdas@...

Chemical examination of the flowers of Parthenium hysterophorus
has resulted in the isolation of four acetylated pseudoguaianolides
along with several known constituents. The structures of the compounds
were derived from detailed studies of their spectral (1D and 2D NMR
and FABMS) data and by comparison of the values with those of
parthenin, a major known constituent of the plant. The cytotoxic
activity of parthenin and the constituents was evaluated using Jurkat
(human: T lymphocyte; acute T cell leukemia), HL-60 (human leukemia)
and Hela (human cervical carcinoma) cells.

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