Parthenium hysterophorus induced changes in neurotransmitter levels in
mouse brain
Sabita Verma 1, Renu Shrivastava 2, P. K. Prasad 3, Vinoy K.
Shrivastava 2 *
1Department of Botany, J.M.D.P.L., Mahila College, Madhubani 847211,
Bihar, India
2Endocrinology Unit, Department of Biosciences, Barkatullah
University, Bhopal 462 026, M.P., India
3V.S.J. College, Rajnagar, Madhubani, Bihar, India
email: Vinoy K. Shrivastava (vinoyks2001@...)

*Correspondence to Vinoy K. Shrivastava, Endocrinology Unit,
Department of Biosciences, Barkatullah University, Bhopal 462 026,
M.P., India.

Keywords
Parthenium hysterophorus � total brain � 5-hydroxytryptamine �
noradrenaline � dopamine

Abstract
Parthenium hysterophorus (10 mg/0.1 ml/kg body weight) was
administered daily to 20 adult male mice and levels of
5-hydroxytryptamine, noradrenaline and dopamine in total brain were
quantified on days 31 and 61 after administration. All
neurotransmitter levels were decreased significantly, with the effects
more prominent in the later part of the experiment. The results
suggest that Parthenium hysterophorus interferes in the functioning of
the hypothalamo-hypophyseal axis by impairing the biogenic amine
levels which may in turn affect the physiology of the peripheral
endocrine glands. Copyright © 2006 John Wiley & Sons, Ltd.

http://www3.interscience.wiley.com/cgi-bin/abstract/113466303/ABSTRACT?CRETRY=1&\
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