http://www.bbc.co.uk/sn/tvradio/programmes/horizon/ghostgenes.shtml
The Ghost in Your Genes
The scientists who believe your genes are shaped in part by your
ancestors' life experiences.


Biology stands on the brink of a shift in the understanding of
inheritance. The discovery of epigenetics - hidden influences upon the genes -
could affect every aspect of our lives.

At the heart of this new field is a simple but contentious idea - that
genes have a 'memory'. That the lives of your grandparents - the air they
breathed, the food they ate, even the things they saw - can directly affect you,
decades later, despite your never experiencing these things yourself. And that
what you do in your lifetime could in turn affect your grandchildren.

The conventional view is that DNA carries all our heritable information
and that nothing an individual does in their lifetime will be biologically
passed to their children. To many scientists, epigenetics amounts to a heresy,
calling into question the accepted view of the DNA sequence - a cornerstone on
which modern biology sits.

Epigenetics adds a whole new layer to genes beyond the DNA. It proposes a
control system of 'switches' that turn genes on or off - and suggests that
things people experience, like nutrition and stress, can control these switches
and cause heritable effects in humans.

In a remote town in northern Sweden there is evidence for this radical
idea. Lying in Överkalix's parish registries of births and deaths and its
detailed harvest records is a secret that confounds traditional scientific
thinking. Marcus Pembrey, a Professor of Clinical Genetics at the Institute of
Child Health in London, in collaboration with Swedish researcher Lars Olov
Bygren, has found evidence in these records of an environmental effect being
passed down the generations. They have shown that a famine at critical times in
the lives of the grandparents can affect the life expectancy of the
grandchildren. This is the first evidence that an environmental effect can be
inherited in humans.

In other independent groups around the world, the first hints that there
is more to inheritance than just the genes are coming to light. The mechanism by
which this extraordinary discovery can be explained is starting to be revealed.

Professor Wolf Reik, at the Babraham Institute in Cambridge, has spent
years studying this hidden ghost world. He has found that merely manipulating
mice embryos is enough to set off 'switches' that turn genes on or off.

For mothers like Stephanie Mullins, who had her first child by in vitro
fertilisation, this has profound implications. It means it is possible that the
IVF procedure caused her son Ciaran to be born with Beckwith-Wiedemann Syndrome
- a rare disorder linked to abnormal gene expression. It has been shown that
babies conceived by IVF have a three- to four-fold increased chance of
developing this condition.

And Reik's work has gone further, showing that these switches themselves
can be inherited. This means that a 'memory' of an event could be passed through
generations. A simple environmental effect could switch genes on or off - and
this change could be inherited.

His research has demonstrated that genes and the environment are not
mutually exclusive but are inextricably intertwined, one affecting the other.

The idea that inheritance is not just about which genes you inherit but
whether these are switched on or off is a whole new frontier in biology. It
raises questions with huge implications, and means the search will be on to find
what sort of environmental effects can affect these switches.

After the tragic events of September 11th 2001, Rachel Yehuda, a
psychologist at the Mount Sinai School of Medicine in New York, studied the
effects of stress on a group of women who were inside or near the World Trade
Center and were pregnant at the time. Produced in conjunction with Jonathan
Seckl, an Edinburgh doctor, her results suggest that stress effects can pass
down generations. Meanwhile research at Washington State University points to
toxic effects - like exposure to fungicides or pesticides - causing biological
changes in rats that persist for at least four generations.

This work is at the forefront of a paradigm shift in scientific thinking.
It will change the way the causes of disease are viewed, as well as the
importance of lifestyles and family relationships. What people do no longer just
affects themselves, but can determine the health of their children and
grandchildren in decades to come. "We are," as Marcus Pembrey says, "all
guardians of our genome."



** The Sky at Night **
Patrick Moore reports on the current close approach of Mars to Earth.
Sunday 6 November, 11.50pm BBC One (N.Ireland: 20 minutes later). Also Tuesday 8
November, 8.30pm BBC Four or Saturday 12 November, 12.50pm BBC Two
http://www.bbc.co.uk/skyatnight


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