Dear Docs, Medicos and Friends of science
Parkinson's therapy trial success http://news.bbc.co.uk/1/hi/health/6059568.stm


Parkinson's is a degenerative condition that effects the brain

Gene therapy has been shown to have "significant" clinical benefits for people
with Parkinson's disease, according to a study.
The small-scale trial showed the 12 patients' symptoms improved by up to 65%
after a year, with no ill effects. The trial was carried out by biotech company
Neurologix Inc, based in the United States. Steve Ford, chief executive of the
Parkinson's Disease Society, described the results as "encouraging". The trials
are the first attempt at using this particular approach to tackle Parkinson's.
The new therapy uses a harmless virus to carry a gene called GAD directly into
neurons in a region of the brain called the subthalamic nucleus (STN). It
produces a molecule called GABA, which is normally released by nerve cells to
inhibit or dampen activity so that the tremors and other symptoms are reduced.
After a year of the trial, all the patients demonstrated a clinical improvement
of at least 25%, judged according to a clinically recognised measure. Nine
patients showed an average improvement of 37%, and five of these demonstrated
substantial recovery of between 40% and 65%. Dr Matthew During, who led the
trial, said: "This gene therapy trial is particularly unique and the clinical
data unusually promising because the treatment was confined to just one side of
the brain."
Incurable disease

Mr Ford also said the Parkinson's Disease Society was interested in the results.
"This type of therapy is still at an early stage of development and the phase 1
trial is encouraging in terms of both safety and effectiveness," he said. "We
look forward to further research being undertaken in this area in the future."
About 120,000 people in the UK have Parkinson's, which causes rigidity and
uncontrollable tremors. Currently incurable, it has to be controlled with drugs
- but this becomes more difficult as the disease progresses. People with
Parkinson's experience insufficient activity from a brain signalling molecule
called dopamine. They either have too few neurons releasing dopamine, or not
enough of the receptors that it stimulates. Because of this imbalance, the STN
becomes highly overactive, which results in Parkinson's symptoms.


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