From: KutchScience

Dear Docs, Medicos and friends of Science and Genetics,

Comments : - Why a nature in human and animals too have a tendency to suck or
lick the part of injury /pain as a natural reflex to relive pain and also saliva
has not only cleaning activity but also antibacterial activity as well as
antibody protections. (Will soon be published NEXT in line) Not only that but
the Human brain is also producing natural painkiller opiorphin which is six
times more powerful than morphine, and when a person is given a placebo as a
control test it may be that pain is relieved by opiorphin released by the human
brain.and so all placebo test for the control / or compare testing will be
invalid as we never understood the brain opiorphin activity and we just compared
control testing with placebo and other pharmaceutical products. It may be that
person having a trust -faith in any alternative drugs or treatment may be having
that opiorphin natural painkiller reliving the pain and so we say TRUST GOD he
will do all well.
Natural-born painkiller found in human saliva
http://www.newscientist.com/article/dn10514-naturalborn-painkiller-found-in-huma\
n-saliva-.html
a.. 22:00 13 November 2006
b.. NewScientist.com news service
c.. Andy Coghlan Saliva from humans has yielded a natural painkiller up to six
times more powerful than morphine, researchers say.
The substance, dubbed opiorphin, may spawn a new generation of natural
painkillers that relieve pain as well as morphine but without the addictive and
psychological side effects of the traditional drug.

When the researchers injected a pain-inducing chemical into rats' paws, 1 gram
of opiorphin per kilogram of body weight achieved the same painkilling effect as
3 grams of morphine.

The substance was so successful at blocking pain that, in a test involving a
platform of upended pins, the rats needed six times as much morphine as
opiorphin to render them oblivious to the pain of standing on the needle points.

Anti-depressive angle
"Its pain-suppressive effect is like that of morphine," says Catherine Rougeot
at the Pasteur Institute in Paris, France, who led the research. "But we have to
test its side effects as it is not a pure painkiller," she says. "It may also be
an anti-depressive molecule."

Rougeot and colleagues discovered that opiorphin works in nerve cells of the
spine by stopping the usual destruction of natural pain-killing opiates there,
called enkephalins.

Opiorphin is such a simple molecule that it should be possible to synthesise it
and produce large quantities without having to isolate it from saliva, Rougeot
explains. Alternatively, it might be possible to find drugs which trigger
patients' bodies to produce more of the molecule themselves.

Journal reference: Proceedings of the National Academy of Sciences (vol 103, p
17979)

Supporting Figure 4 Fig. 4. Human Opiorphin demonstrates inhibitory potency of
enkephalin-degrading ectopeptidases. (A) Concentration-dependent inhibition by
QRFSR peptide of Mca-BK2 cleavage by hNEP expressed at the cell surface of
recombinant HEK293 cells. (B) Concentration-dependent inhibition by QRFSR
peptide of Ala-pNA cleavage by hAP-N expressed at the cell surface of
recombinant HEK293 cells. Each point represents the specific endopeptidase
(white diamond, A) or aminopeptidase (black diamond, B) activity, expressed in
relative fluorescent units (RFU)/min per mg or mA405/min per mg of membrane
protein, respectively, which was measured in the absence or in the presence of
various concentrations of QRFSR peptide (in mM).


Supporting Figure 5 Fig. 5. Opiorphin-derived peptide displays potent analgesic
activity in pain rat model. Evaluation of the pain response of rats to noxious
chemical stimuli after administration of QRFSR-derivative peptide. The tests
were performed 15 min after injecting rats with QRFSR-derived peptide or vehicle
via the tail vein. Dose-dependent antinociceptive effects of YQRFSR peptide on
the duration of paw licking (A) and number of body tremors (B) during the three
20-min periods of the formalin test (0- to 20-min early phase; 40- to 60-min
late phase). The values represent the mean ± SEM of eight animals for each
condition: vehicle, white circle; YQRFSR peptide at 0.5 mg/kg dose, white
diamond; YQRFSR peptide at 1 mg/kg dose, black diamond. *, P < 0.05, **, P <
0.01, and ***, P < 0.001 by Dunnett's t test.

ALSO read followings

News - Olive oil 'acts like painkiller' Good quality olive oil contains a
natural chemical that acts in a similar way to a painkiller, a study says..

News - Natural pain relief Scientists have discovered that the body's immune
system produces a natural painkiller which could be used to develop a new
generation of analgesics..
Forwarded By yours Dr.BHUDIA-Science Group Of INDIA.
http://uk.groups.yahoo.com/group/venustransit_2004/
President:"Kutch Science Foundation".
Founder :"Kutch Amateurs Astronomers Club - Bhuj - Kutch".
Life Member:"kutch Itihaas Parishad".
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